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tissue specific gene expression data  (Human Protein Atlas)

 
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    Human Protein Atlas tissue specific gene expression data
    (A) Cohen’s h values for pairwise comparisons between 𝒞 and the other two groups: ℬ and ℐ . Primate <t>Specific</t> Ratios are calculated as in . A higher absolute Cohen’s h indicates a greater difference in ratios between the two compared groups. Green bar represents ℬ , orange bar represents ℐ , and blue bars represent 𝒞 . (B) Results of Fisher’s exact tests for pairwise comparisons between each of ℬ , ℐ , and 𝒞 and each control group ( ℱ and ℛ ), together with the comparison between ℱ and ℛ . Primate Specific Ratios are calculated as in . Statistical significance is denoted by asterisks. Results with p-values less than 0.01 are indicated by two asterisks (**), results with p-values less than 0.05 are indicated by one asterisk (*), and all other results are marked as ns . Green bar represents ℬ , orange bar represents ℐ , blue bar represents 𝒞 , gray bars represent ℛ , and purple bars represent ℱ . (C) The number of tissues corresponding to each quantile for the brain <t>genes</t> and immune-related genes. Green bars represent ℬ , orange bars represent ℐ , and gray bars represent all genes that have at least one highly expressed <t>tissue</t> in Human Protein Atlas [ , ]. (D) The number and ratio of genes highly expressed specifically in brain tissues or immune-related tissues, out of 1019 brain genes and 586 immune-related genes, respectively.
    Tissue Specific Gene Expression Data, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/tissue-specific+expression+data/specific+tissue/pmc13160339-156-27-35
    Average 86 stars, based on 1 article reviews
    tissue specific gene expression data - by Bioz Stars, 2026-09
    86/100 stars

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    1) Product Images from "Comparative genomics of human brain and immune gene preservation across species"

    Article Title: Comparative genomics of human brain and immune gene preservation across species

    Journal: PLOS One

    doi: 10.1371/journal.pone.0348713

    (A) Cohen’s h values for pairwise comparisons between 𝒞 and the other two groups: ℬ and ℐ . Primate Specific Ratios are calculated as in . A higher absolute Cohen’s h indicates a greater difference in ratios between the two compared groups. Green bar represents ℬ , orange bar represents ℐ , and blue bars represent 𝒞 . (B) Results of Fisher’s exact tests for pairwise comparisons between each of ℬ , ℐ , and 𝒞 and each control group ( ℱ and ℛ ), together with the comparison between ℱ and ℛ . Primate Specific Ratios are calculated as in . Statistical significance is denoted by asterisks. Results with p-values less than 0.01 are indicated by two asterisks (**), results with p-values less than 0.05 are indicated by one asterisk (*), and all other results are marked as ns . Green bar represents ℬ , orange bar represents ℐ , blue bar represents 𝒞 , gray bars represent ℛ , and purple bars represent ℱ . (C) The number of tissues corresponding to each quantile for the brain genes and immune-related genes. Green bars represent ℬ , orange bars represent ℐ , and gray bars represent all genes that have at least one highly expressed tissue in Human Protein Atlas [ , ]. (D) The number and ratio of genes highly expressed specifically in brain tissues or immune-related tissues, out of 1019 brain genes and 586 immune-related genes, respectively.
    Figure Legend Snippet: (A) Cohen’s h values for pairwise comparisons between 𝒞 and the other two groups: ℬ and ℐ . Primate Specific Ratios are calculated as in . A higher absolute Cohen’s h indicates a greater difference in ratios between the two compared groups. Green bar represents ℬ , orange bar represents ℐ , and blue bars represent 𝒞 . (B) Results of Fisher’s exact tests for pairwise comparisons between each of ℬ , ℐ , and 𝒞 and each control group ( ℱ and ℛ ), together with the comparison between ℱ and ℛ . Primate Specific Ratios are calculated as in . Statistical significance is denoted by asterisks. Results with p-values less than 0.01 are indicated by two asterisks (**), results with p-values less than 0.05 are indicated by one asterisk (*), and all other results are marked as ns . Green bar represents ℬ , orange bar represents ℐ , blue bar represents 𝒞 , gray bars represent ℛ , and purple bars represent ℱ . (C) The number of tissues corresponding to each quantile for the brain genes and immune-related genes. Green bars represent ℬ , orange bars represent ℐ , and gray bars represent all genes that have at least one highly expressed tissue in Human Protein Atlas [ , ]. (D) The number and ratio of genes highly expressed specifically in brain tissues or immune-related tissues, out of 1019 brain genes and 586 immune-related genes, respectively.

    Techniques Used: Control, Comparison

    Related Articles

    Gene Expression:

    Article Title: HUBMet: an integrative database and analytical platform for human blood metabolites and metabolite-protein associations
    Article Snippet: .. By leveraging tissue-specific gene expression data from the Human Protein Atlas and combining it with metabolite-protein associations, we established a computational framework to infer the likely tissue/organ origins or functional contexts of blood metabolites. ..

    Article Title: HUBMet: An integrative database and analytical platform for human blood metabolites and metabolite-protein associations
    Article Snippet: .. By leveraging tissue-specific gene expression data from the Human Protein Atlas and combining it with metabolite-protein associations, we established a computational framework to infer the likely tissue/organ origins or functional contexts of blood metabolites. ..

    Article Title: Comparative genomics of human brain and immune gene preservation across species.
    Article Snippet: .. There are six types of data used in this work: (1) CDS (coding sequence) data of 32 primate species and 4 non-primate species [30,31]; (2) tissue specific gene expression data obtained from the Human Protein Atlas 23.0 [32,33]; (3) 1360 human genes highly expressed in the brain or the immune system [32,33]; (4) 295 random human genes selected using the random.sample() function in Python 3.10.8; (5) 369 human genes each from a distinct HGNC [27] gene family group; and (6) protein sequences of the genes obtained from UniProt [34]. ..

    Article Title: Comparative genomics of human brain and immune gene preservation across species
    Article Snippet: .. There are six types of data used in this work: (1) CDS (coding sequence) data of 32 primate species and 4 non-primate species [ , ]; (2) tissue specific gene expression data obtained from the Human Protein Atlas 23.0 [ , ]; (3) 1360 human genes highly expressed in the brain or the immune system [ , ]; (4) 295 random human genes selected using the random.sample() function in Python 3.10.8; (5) 369 human genes each from a distinct HGNC [ ] gene family group; and (6) protein sequences of the genes obtained from UniProt [ ]. ..

    Article Title: HUBMet: an integrative database and analytical platform for human blood metabolites and metabolite-protein associations.
    Article Snippet: .. By leveraging tissue-specific gene expression data from the Human Protein Atlas and combining it with metabolite-protein associations, we established a computational framework to infer the likely tissue/organ origins or functional contexts of blood metabolites. ..

    Article Title: Temporal Biodynamics: An AI Platform for Identification of Stage-Relevant Targets and Biomarkers
    Article Snippet: .. Liver-specific genes were identified using RNA expression data from the Human Protein Atlas (HPA) consensus tissue gene expression dataset. ..

    Functional Assay:

    Article Title: HUBMet: an integrative database and analytical platform for human blood metabolites and metabolite-protein associations
    Article Snippet: .. By leveraging tissue-specific gene expression data from the Human Protein Atlas and combining it with metabolite-protein associations, we established a computational framework to infer the likely tissue/organ origins or functional contexts of blood metabolites. ..

    Article Title: HUBMet: An integrative database and analytical platform for human blood metabolites and metabolite-protein associations
    Article Snippet: .. By leveraging tissue-specific gene expression data from the Human Protein Atlas and combining it with metabolite-protein associations, we established a computational framework to infer the likely tissue/organ origins or functional contexts of blood metabolites. ..

    Article Title: The role of MRGPRX1 in the melanogenesis of human primary epidermal melanocytes.
    Article Snippet: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record.. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article.. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

    Article Title: HUBMet: an integrative database and analytical platform for human blood metabolites and metabolite-protein associations.
    Article Snippet: .. By leveraging tissue-specific gene expression data from the Human Protein Atlas and combining it with metabolite-protein associations, we established a computational framework to infer the likely tissue/organ origins or functional contexts of blood metabolites. ..

    Binding Assay:

    Article Title: Human proteome-wide molecular interaction analysis based on AlphaFold3 to evaluate toxicity between PFOS and its alternative F-53B.
    Article Snippet: F-53B, primarily composed of 6:2 chlorinated polyfluoroalkyl ether sulfonate (Cl-PFESA) and 8:2 Cl-PFESA, has been widely used as an alternative to perfluorooctane sulfonic acid (PFOS), but emerging evidence indicates that F-53B also exhibits toxicity and may not be a safe substitute.. We conducted systematic molecular interaction analysis between three compounds PFOS, 6:2 Cl-PFESA, and 8:2 Cl-PFESA and 19,508 human proteins using AlphaFold3-predicted three-dimensional structures combined with AutoDock Vina molecular docking.. Binding affinity distributions, compound-specific binding patterns, and functional enrichment analyses were performed to identify differential toxicity mechanisms.

    Expressing:

    Article Title: Human proteome-wide molecular interaction analysis based on AlphaFold3 to evaluate toxicity between PFOS and its alternative F-53B.
    Article Snippet: F-53B, primarily composed of 6:2 chlorinated polyfluoroalkyl ether sulfonate (Cl-PFESA) and 8:2 Cl-PFESA, has been widely used as an alternative to perfluorooctane sulfonic acid (PFOS), but emerging evidence indicates that F-53B also exhibits toxicity and may not be a safe substitute.. We conducted systematic molecular interaction analysis between three compounds PFOS, 6:2 Cl-PFESA, and 8:2 Cl-PFESA and 19,508 human proteins using AlphaFold3-predicted three-dimensional structures combined with AutoDock Vina molecular docking.. Binding affinity distributions, compound-specific binding patterns, and functional enrichment analyses were performed to identify differential toxicity mechanisms.

    Article Title: The role of MRGPRX1 in the melanogenesis of human primary epidermal melanocytes.
    Article Snippet: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record.. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article.. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

    Sequencing:

    Article Title: Comparative genomics of human brain and immune gene preservation across species.
    Article Snippet: .. There are six types of data used in this work: (1) CDS (coding sequence) data of 32 primate species and 4 non-primate species [30,31]; (2) tissue specific gene expression data obtained from the Human Protein Atlas 23.0 [32,33]; (3) 1360 human genes highly expressed in the brain or the immune system [32,33]; (4) 295 random human genes selected using the random.sample() function in Python 3.10.8; (5) 369 human genes each from a distinct HGNC [27] gene family group; and (6) protein sequences of the genes obtained from UniProt [34]. ..

    Article Title: Comparative genomics of human brain and immune gene preservation across species
    Article Snippet: .. There are six types of data used in this work: (1) CDS (coding sequence) data of 32 primate species and 4 non-primate species [ , ]; (2) tissue specific gene expression data obtained from the Human Protein Atlas 23.0 [ , ]; (3) 1360 human genes highly expressed in the brain or the immune system [ , ]; (4) 295 random human genes selected using the random.sample() function in Python 3.10.8; (5) 369 human genes each from a distinct HGNC [ ] gene family group; and (6) protein sequences of the genes obtained from UniProt [ ]. ..

    RNA Expression:

    Article Title: Temporal Biodynamics: An AI Platform for Identification of Stage-Relevant Targets and Biomarkers
    Article Snippet: .. Liver-specific genes were identified using RNA expression data from the Human Protein Atlas (HPA) consensus tissue gene expression dataset. ..



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    (A) Cohen’s h values for pairwise comparisons between 𝒞 and the other two groups: ℬ and ℐ . Primate <t>Specific</t> Ratios are calculated as in . A higher absolute Cohen’s h indicates a greater difference in ratios between the two compared groups. Green bar represents ℬ , orange bar represents ℐ , and blue bars represent 𝒞 . (B) Results of Fisher’s exact tests for pairwise comparisons between each of ℬ , ℐ , and 𝒞 and each control group ( ℱ and ℛ ), together with the comparison between ℱ and ℛ . Primate Specific Ratios are calculated as in . Statistical significance is denoted by asterisks. Results with p-values less than 0.01 are indicated by two asterisks (**), results with p-values less than 0.05 are indicated by one asterisk (*), and all other results are marked as ns . Green bar represents ℬ , orange bar represents ℐ , blue bar represents 𝒞 , gray bars represent ℛ , and purple bars represent ℱ . (C) The number of tissues corresponding to each quantile for the brain <t>genes</t> and immune-related genes. Green bars represent ℬ , orange bars represent ℐ , and gray bars represent all genes that have at least one highly expressed <t>tissue</t> in Human Protein Atlas [ , ]. (D) The number and ratio of genes highly expressed specifically in brain tissues or immune-related tissues, out of 1019 brain genes and 586 immune-related genes, respectively.
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    (A) Cohen’s h values for pairwise comparisons between 𝒞 and the other two groups: ℬ and ℐ . Primate <t>Specific</t> Ratios are calculated as in . A higher absolute Cohen’s h indicates a greater difference in ratios between the two compared groups. Green bar represents ℬ , orange bar represents ℐ , and blue bars represent 𝒞 . (B) Results of Fisher’s exact tests for pairwise comparisons between each of ℬ , ℐ , and 𝒞 and each control group ( ℱ and ℛ ), together with the comparison between ℱ and ℛ . Primate Specific Ratios are calculated as in . Statistical significance is denoted by asterisks. Results with p-values less than 0.01 are indicated by two asterisks (**), results with p-values less than 0.05 are indicated by one asterisk (*), and all other results are marked as ns . Green bar represents ℬ , orange bar represents ℐ , blue bar represents 𝒞 , gray bars represent ℛ , and purple bars represent ℱ . (C) The number of tissues corresponding to each quantile for the brain <t>genes</t> and immune-related genes. Green bars represent ℬ , orange bars represent ℐ , and gray bars represent all genes that have at least one highly expressed <t>tissue</t> in Human Protein Atlas [ , ]. (D) The number and ratio of genes highly expressed specifically in brain tissues or immune-related tissues, out of 1019 brain genes and 586 immune-related genes, respectively.
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    (A) Cohen’s h values for pairwise comparisons between 𝒞 and the other two groups: ℬ and ℐ . Primate <t>Specific</t> Ratios are calculated as in . A higher absolute Cohen’s h indicates a greater difference in ratios between the two compared groups. Green bar represents ℬ , orange bar represents ℐ , and blue bars represent 𝒞 . (B) Results of Fisher’s exact tests for pairwise comparisons between each of ℬ , ℐ , and 𝒞 and each control group ( ℱ and ℛ ), together with the comparison between ℱ and ℛ . Primate Specific Ratios are calculated as in . Statistical significance is denoted by asterisks. Results with p-values less than 0.01 are indicated by two asterisks (**), results with p-values less than 0.05 are indicated by one asterisk (*), and all other results are marked as ns . Green bar represents ℬ , orange bar represents ℐ , blue bar represents 𝒞 , gray bars represent ℛ , and purple bars represent ℱ . (C) The number of tissues corresponding to each quantile for the brain <t>genes</t> and immune-related genes. Green bars represent ℬ , orange bars represent ℐ , and gray bars represent all genes that have at least one highly expressed <t>tissue</t> in Human Protein Atlas [ , ]. (D) The number and ratio of genes highly expressed specifically in brain tissues or immune-related tissues, out of 1019 brain genes and 586 immune-related genes, respectively.
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    (A) Cohen’s h values for pairwise comparisons between 𝒞 and the other two groups: ℬ and ℐ . Primate <t>Specific</t> Ratios are calculated as in . A higher absolute Cohen’s h indicates a greater difference in ratios between the two compared groups. Green bar represents ℬ , orange bar represents ℐ , and blue bars represent 𝒞 . (B) Results of Fisher’s exact tests for pairwise comparisons between each of ℬ , ℐ , and 𝒞 and each control group ( ℱ and ℛ ), together with the comparison between ℱ and ℛ . Primate Specific Ratios are calculated as in . Statistical significance is denoted by asterisks. Results with p-values less than 0.01 are indicated by two asterisks (**), results with p-values less than 0.05 are indicated by one asterisk (*), and all other results are marked as ns . Green bar represents ℬ , orange bar represents ℐ , blue bar represents 𝒞 , gray bars represent ℛ , and purple bars represent ℱ . (C) The number of tissues corresponding to each quantile for the brain <t>genes</t> and immune-related genes. Green bars represent ℬ , orange bars represent ℐ , and gray bars represent all genes that have at least one highly expressed <t>tissue</t> in Human Protein Atlas [ , ]. (D) The number and ratio of genes highly expressed specifically in brain tissues or immune-related tissues, out of 1019 brain genes and 586 immune-related genes, respectively.
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    (A) Cohen’s h values for pairwise comparisons between 𝒞 and the other two groups: ℬ and ℐ . Primate <t>Specific</t> Ratios are calculated as in . A higher absolute Cohen’s h indicates a greater difference in ratios between the two compared groups. Green bar represents ℬ , orange bar represents ℐ , and blue bars represent 𝒞 . (B) Results of Fisher’s exact tests for pairwise comparisons between each of ℬ , ℐ , and 𝒞 and each control group ( ℱ and ℛ ), together with the comparison between ℱ and ℛ . Primate Specific Ratios are calculated as in . Statistical significance is denoted by asterisks. Results with p-values less than 0.01 are indicated by two asterisks (**), results with p-values less than 0.05 are indicated by one asterisk (*), and all other results are marked as ns . Green bar represents ℬ , orange bar represents ℐ , blue bar represents 𝒞 , gray bars represent ℛ , and purple bars represent ℱ . (C) The number of tissues corresponding to each quantile for the brain <t>genes</t> and immune-related genes. Green bars represent ℬ , orange bars represent ℐ , and gray bars represent all genes that have at least one highly expressed <t>tissue</t> in Human Protein Atlas [ , ]. (D) The number and ratio of genes highly expressed specifically in brain tissues or immune-related tissues, out of 1019 brain genes and 586 immune-related genes, respectively.
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    Image Search Results


    (A) Cohen’s h values for pairwise comparisons between 𝒞 and the other two groups: ℬ and ℐ . Primate Specific Ratios are calculated as in . A higher absolute Cohen’s h indicates a greater difference in ratios between the two compared groups. Green bar represents ℬ , orange bar represents ℐ , and blue bars represent 𝒞 . (B) Results of Fisher’s exact tests for pairwise comparisons between each of ℬ , ℐ , and 𝒞 and each control group ( ℱ and ℛ ), together with the comparison between ℱ and ℛ . Primate Specific Ratios are calculated as in . Statistical significance is denoted by asterisks. Results with p-values less than 0.01 are indicated by two asterisks (**), results with p-values less than 0.05 are indicated by one asterisk (*), and all other results are marked as ns . Green bar represents ℬ , orange bar represents ℐ , blue bar represents 𝒞 , gray bars represent ℛ , and purple bars represent ℱ . (C) The number of tissues corresponding to each quantile for the brain genes and immune-related genes. Green bars represent ℬ , orange bars represent ℐ , and gray bars represent all genes that have at least one highly expressed tissue in Human Protein Atlas [ , ]. (D) The number and ratio of genes highly expressed specifically in brain tissues or immune-related tissues, out of 1019 brain genes and 586 immune-related genes, respectively.

    Journal: PLOS One

    Article Title: Comparative genomics of human brain and immune gene preservation across species

    doi: 10.1371/journal.pone.0348713

    Figure Lengend Snippet: (A) Cohen’s h values for pairwise comparisons between 𝒞 and the other two groups: ℬ and ℐ . Primate Specific Ratios are calculated as in . A higher absolute Cohen’s h indicates a greater difference in ratios between the two compared groups. Green bar represents ℬ , orange bar represents ℐ , and blue bars represent 𝒞 . (B) Results of Fisher’s exact tests for pairwise comparisons between each of ℬ , ℐ , and 𝒞 and each control group ( ℱ and ℛ ), together with the comparison between ℱ and ℛ . Primate Specific Ratios are calculated as in . Statistical significance is denoted by asterisks. Results with p-values less than 0.01 are indicated by two asterisks (**), results with p-values less than 0.05 are indicated by one asterisk (*), and all other results are marked as ns . Green bar represents ℬ , orange bar represents ℐ , blue bar represents 𝒞 , gray bars represent ℛ , and purple bars represent ℱ . (C) The number of tissues corresponding to each quantile for the brain genes and immune-related genes. Green bars represent ℬ , orange bars represent ℐ , and gray bars represent all genes that have at least one highly expressed tissue in Human Protein Atlas [ , ]. (D) The number and ratio of genes highly expressed specifically in brain tissues or immune-related tissues, out of 1019 brain genes and 586 immune-related genes, respectively.

    Article Snippet: There are six types of data used in this work: (1) CDS (coding sequence) data of 32 primate species and 4 non-primate species [ , ]; (2) tissue specific gene expression data obtained from the Human Protein Atlas 23.0 [ , ]; (3) 1360 human genes highly expressed in the brain or the immune system [ , ]; (4) 295 random human genes selected using the random.sample() function in Python 3.10.8; (5) 369 human genes each from a distinct HGNC [ ] gene family group; and (6) protein sequences of the genes obtained from UniProt [ ].

    Techniques: Control, Comparison